Studies on the Disposition of Fadrozole Hydrochloride (CGS 1 6949A) (II): Absorption, Distribution, Metabolism and Excretion after Repeated Oral Administration to Rats.
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Absorption, distribution, metabolism, and excretion of donepezil (Aricept) after a single oral administration to Rat.
Donepezil hydrochloride (Aricept) is a drug for the treatment of Alzheimer's disease. The absorption, distribution, metabolism, and excretion of donepezil were investigated in male Sprague-Dawley rats after a single oral administration. Orally administered (14)C-labeled donepezil was absorbed rapidly. The plasma level of unchanged donepezil declined more rapidly than that of radioactivity, and ...
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ژورنال
عنوان ژورنال: Drug Metabolism and Pharmacokinetics
سال: 1993
ISSN: 0916-1139
DOI: 10.2133/dmpk.8.1129